v2.0.0Latest
Final Validated Release
New Features
- Optimized 30 core disease PRS models for final FDA De Novo submission (reduced from 30 based on All of Us validation).
Security
- Mandatory TOTP-based multi-factor authentication (MFA) enforced for all user accounts via AWS Cognito.
- Enhanced password policy requiring uppercase, lowercase, numeric, and special characters.
- Session inactivity timeout set to 15 minutes to prevent unauthorized access.
Enhancements
- Finalized UI authentication flow and user experience improvements.
Validation
- Confirmed reproducibility across all validation datasets (UK Biobank, Framingham Heart Study, All of Us).
v1.5.0
Security & Stability (Pre-Release)
New Features
- Native support for compressed genotype files (.vcf.gz).
Security
- ISO 27001 Information Security Management System (ISMS) certification obtained.
- TLS 1.2+ enforcement across all communications.
- Comprehensive audit logging via AWS CloudTrail.
Bug Fixes
- Corrected timezone-related demographic data formatting.
v1.2.0
Longitudinal Validation & Reporting
Enhancements
- Enhanced PDF reporting format for clinical readability.
Validation
- Integrated longitudinal validation with Framingham Heart Study (FHS).
Bug Fixes
- Fixed download link activation logic.
- Hardened data integrity by resolving Base64 encoding and special character handling issues.
v1.1.0
Optimization & Reproducibility
Enhancements
- Performance optimization for large VCF uploads (up to 20 GB).
- Refined dashboard UI and risk percentile visualization aligned with clinical reference standards.
Validation
- Added cross-cohort reproducibility testing (All of Us, FinnGen).
v1.0.0
Full Model Implementation
New Features
- Full implementation of PRS models for 30 diseases with HR2/HR3 cutoff logic.
Enhancements
- Added pagination for result tables and real-time status tracking.
Validation
- Validated on UK Biobank 56K independent subset.